Browse Genes by Chromosome

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Gene Alias GO Phenotype Description
YAL001C FUN24|TSV115 transcription factor tau (TFIIIC) subunit Null Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YAL002W FUN15|VPT8 membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2+ binding motif Null mutant is viable, missorts and secretes vacuolar hydrolases, overexpression of VPS21 partially suppresses vps8 null Membrane-associated hydrophilic protein that interacts with the small GTPase, Vps21p, to facilitate soluble vacuolar protein localization; required for localization and trafficking of the CPY sorting receptor; contains a RING finger motif
YAL003W EF-1 beta|TEF5 translation elongation factor EF-1beta Null Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YAL005C YG100 heat shock protein of HSP70 family Null mutant is viable, temperature sensitive; ssa1 ssa2 ssa4 strains are inviable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YAL007C Null p24 protein involved in membrane trafficking null mutant is viable; delayed transport of Gas1p Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YAL008W Null Null Null Mitochondrial protein of unknown function
YAL009W Null Null Null mutant is viable, sporulation defective Integral nuclear/ER membrane protein of unknown function, required for normal nuclear envelope morphology and sporulation
YAL010C FUN37 mitochondrial outer membrane protein Null mutant has short actin cables. Point mutants exhibit giant, spherical mitochondria and are defective for mitochondrial inheritance. Subunit of the mitochondrial sorting and assembly machinery (SAM complex); has a role in assembly of the TOM complex, which mediates protein import through the outer membrane; required for normal mitochondrial morphology and inheritance
YAL011W SWC1 Null Null Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
YAL012W CYI1|FUN35|STR1 cystathionine gamma-lyase Null mutant is viable, cysteine auxotroph Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine;
YAL013W FUN54 Null Null Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
YAL014C SLT2|UIP2 syntaxin family Null Endosomal SNARE related to mammalian syntaxin 8
YAL015C FUN33|SCR1 DNA glycosylase Null mutant is viable but is sensitive to H202 and menadione DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion
YAL016W FUN32 protein phosphatase 2A regulatory subunit A Null mutant is viable, defective in cytokinesis at reduced temperatures, defective in transcription by RNA polymerase III at elevated temperatures; nocodazole sensitive and exhibits phenotypes of previously identified kinetochore/spindle checkpoint mutants Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III
YAL017W FUN31 Null Null One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YAL019W Null Null Null Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p
YAL020C FUN28|KTI13 Null slow growth Protein with a potential role in regulatory interactions between microtubules and the cell cycle, as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1
YAL021C FUN27|NUT21 Null reduced levels of ADH2 expression under both glucose and ethanol growth conditions; temperature sensitive growth on nonfermentative medium Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
YAL022C Null Null Null Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes
YAL023C FUN25 dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase Null mutants are viable but show diminished in vitro and in vivo O-mannosylation activity; pmt1 pmt2 double mutant shows severe growth defect but has residual O-mannosylation activity; pmt2 pmt3 pmt4 triple mutant is inviable Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
YAL024C MSI2 Null lethal at low temperature (8 degrees C) Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
YAL025C Null nuclear protein (putative) Null mutant is inviable, conditional mutants arrest at G(sub)1, are deficient in maintenance of killer M1 double-stranded RNA Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for normal concentration of free 60S ribosomal subunits; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YAL026C FUN38|SWA3 P-type ATPase, potential aminophospholipid translocase Null mutant is viable, cold sensitive with perturbed late Golgi function; drs2 arf1 double mutants are inviable. drs2 dnf1 mutants grow slowly, accumulate intracellular membranes, exhibit substantial defect in transport of alkaline phosphatase to vacuole. Integral membrane Ca(2+)-ATPase involved in aminophospholipid translocation; required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption; mutation affects maturation of the 18S rRNA
YAL028W HPH2 Null Null Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
YAL029C FUN22|SHE1 myosin V heavy chain Null mutant is viable, has no detectable phenotype, either alone or in conjunction with mutations in other myosin genes. Overexpression of MYO4 results in several morphological abnormalities, including the formation of short strings of unseparated cells in diploid strains, or clusters of cells in haploid strains One of two type V myosins; required for mother-specific HO expression, for the bud tip localization of ASH1 and IST2 mRNA; facilitates growth and orientation of ER tubules along with She3p
YAL030W Null Snc2p homolog|synaptobrevin homolog Null mutant is viable; snc1 snc2 mutants are deficient in normal bulk secretion, accumulate large numbers of post-Golgi vesicles, and display a variety of conditional lethal phenotypes; snc1 mutations suppress loss of cap in strains possessing an activated ras2 allele Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YAL031C FUN21 Null Null Cytoplasmic Glc7p-interacting protein, potential Cdc28p substrate
YAL032C FUN20 pre-mRNA splicing factor Null Ortholog of human transcriptional coactivator SKIP, can activate transcription of a reporter gene; interacts with splicing factors Prp22p and Prp46p
YAL033W FUN53 Nuclear RNase P subunit|RNase MRP subunit Null mutant is inviable; transient depletion of Pop5p causes loss of RNase P and RNase MRP function Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YAL034C Null Null Null Non-essential protein of unknown function
YAL034W-A DSN3|NSL2 Null Null mutant is inviable. ts mtw1 mutant exhibits longer metaphase spindles and unequal sister chromatid segregation Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
YAL035W eIF5B|yIF2 97 kDa protein Null GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
YAL036C FUN11 Null Null Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes
YAL038W PYK1 pyruvate kinase Null mutant is inviable. cdc19 mutants are pyruvate kinase deficient and show cell division cycle blocked at 36 degrees C Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YAL039C Null cytochrome c heme lyase (CCHL) Cytochrome c deficiency Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-Cyc1p in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YAL040C DAF1|FUN10|WHI1 G1 cyclin Null mutant is viable; dominant mutation causes alpha-factor resistance and small cell size; chromosomal deletion increases cell volume G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
YAL041W CLS4 guanine nucleotide exchange factor (a.k.a. GDP-release factor) for cdc42 temperature sensitive mutation affecting bud formation and localized cell surface growth at a restrictive temperature Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing
YAL042W FUN9 ER-Golgi transport vesicle protein Null Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
YAL043C FUN39 cleavage factor II (CF II) component|polyadenylation factor I (PF I) Null mutant is inviable; temperature-sensitive mutant shows defects in pre-tRNA processing Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
YAL044C Null glycine cleavage system H-protein subunit Null mutant is viable but does not grow if glycine is the sole nitrogen source H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YAL047C LDB4 Null Null mutant is inviable. Cells lacking Spc72 can only generate very short (<1 micron) and unstable astral microtubules. Consequently, nuclear migration to the bud neck and orientation of the anaphase spindle along the mother-bud axis are absent in these cells. Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
YAL048C GON1 Null Null mutant is viable but exhibits slightly reduced secretion of over-produced PrA. Null mutants also grow slowly in the presence of high concentrations of calcium. Overexpression enhances secretion of overexpressed PrA. Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death
YAL051W YAF1 transcription factor Null Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
YAL053W HUF2 Null Null Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YAL054C FUN44 acetyl CoA synthetase Null mutant is viable and grows on ethanol or glucose (but not acetate) as sole carbon source (but with long lag-phase); acs1 acs2 double null mutant is inviable Acetyl-coA synthetase isoform, expressed during growth on nonfermentable carbon sources and under aerobic conditions
YAL055W YAF5 Null Null mutant is viable and oleate minus Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation
YAL056W KRH1 Null Deletion causes a high PKA phenotype. Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p, has signaling role in response to nutrients; involved in regulation of pseudohyphal growth through cAMP levels; homolog of Gpb1p
YAL058W FUN48 calnexin and calreticulin homolog Null mutant is viable, increase of cell-surface expression of ste2-3p, increase in secretion of heterologously expressed mammalian alpha 1-antitrypsin. ~30% decrease in beta-1,6-glucan upon disruption of CNE1. Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
YAL059W Null Null Null Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YAL060W Null Null Null NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, a zinc-containing medium-chain alcohol dehydrogenase, produces 2,3-butanediol from acetoin during fermentation and allows using 2,3-butanediol as a carbon source during aerobic growth
YAL062W FUN51 NADP-linked glutamate dehydrogenase Null NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YAL063C Null similar to FLO1 Null Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YAL067C Null permease (putative) Null Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YAL068C Null Null Null Hypothetical protein
YAR002C-A Null p24 protein involved in membrane trafficking null mutant is viable; delayed transport of Gas1p and invertase Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YAR002W Null nuclear pore complex subunit Null Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YAR003W CPS50|FUN16|SAF49 compass (complex proteins associated with Set1p) component Null: defective in silencing of expression of genes located near telomeres; hydroxyurea sensitive. Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
YAR007C BUF2|FUN3|RPA1 RF-A|heterotrimeric RPA (RF-A) single-stranded DNA binding protein 69 kDa subunit Null mutant is inviable; cells lacking RFA1 accumulate as multiply budded cells with a single nucleus suggesting a defect in DNA replication; rfa1 repair defects are suppressed by high copy RAD52 Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YAR008W FUN4 tetrameric tRNA splicing endonuclease 34 kDa subunit Null mutant is inviable and shows H242A impaired 3'splice site cleavage Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YAR014C Null Null Null Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YAR015W Null phosphoribosyl amino imidazolesuccinocarbozamide synthetase Null mutant is viable and adenine auxotroph; ade1 mutants produce red pigment when grown in media containing low lvels of adenine. N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
YAR018C FUN52|NPK1 protein kinase Null Nonessential protein kinase with unknown cellular role
YAR019C LYT1 protein kinase domain Null mutant inviable, arrests in G2; buds at distal instead of axial position, undergoes autolysis when buds reach the size of mother cells; the mitotic, but not meiotic, phenotype is suppressible by overexpressing SPO12. Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YAR020C Null Null Null Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YAR027W Null Null Null Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YAR031W Null Null Null Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
YAR033W Null Null Null Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles
YAR035W Null carnitine acetyltransferase Null mutant is viable, yields no obvious phenotype on any carbon source Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix
YAR042W OSH1|YAR044W Null Null Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
YAR050W FLO2|FLO4 Null Flocculation Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YAR071W Null acid phosphatase phosphatase deficient One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YAR073W Null IMP dehydrogenase homolog Null Nonfunctional protein with homology to IMP dehydrogenase; probable pseudogene, located close to the telomere; is not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae