Kim Lab of Computational Evolutionary Biology
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Biology Department
School of Arts and Sciences
University of Pennsylvania
103I Lynch Laboratory
433 S University Avenue
Philadelphia, PA 19104 USA

off: (215) 746-5187
lab: (215) 898-8395
fax: (215) 898-8780

email: junhyong@sas.upenn.edu

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KimSalisbury01

A phylogeny is a tree graph representation of genealogical relationships between biological objects. It is of general interest to estimate the phylogeny of whole organisms (species trees) using bio-molecular sequences. When multiple sequences are available for each organism such as with whole genome data, individual phylogenies estimated by each molecule (gene trees) may not be concordant. The lack of concordance may be due to actual biological mechanisms such as horizontal transfer of the molecules. Here, we present a new phylogeny estimation method designed to estimate the species tree despite such horizontal transfer. It uses the idea that horizontal transfer distorts distance relationships between pairs of species but a median estimate of the distances is robust to such distortions. We demonstrate the utility of our method using a simulation study.


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